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Year : 2018  |  Volume : 4  |  Issue : 1  |  Page : 34-35

Radio-pathological correlation of mycosis fungoides

Department of Radiology, Malabar Medical College, Kozhikode, Kerala, India

Date of Web Publication19-Jul-2018

Correspondence Address:
Dr. Reddy Ravikanth
Department of Radiology, Malabar Medical College, Kozhikode - 673 315, Kerala
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ASJO.ASJO_24_18

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How to cite this article:
Ravikanth R, Chandrasekhar A. Radio-pathological correlation of mycosis fungoides. Asian J Oncol 2018;4:34-5

How to cite this URL:
Ravikanth R, Chandrasekhar A. Radio-pathological correlation of mycosis fungoides. Asian J Oncol [serial online] 2018 [cited 2019 Feb 22];4:34-5. Available from: http://www.asjo.in/text.asp?2018/4/1/34/237171

Dear Sir,

A 52-year-old male presented to the dermatology department on account of itching for 3 years and mild hypoanesthesia of the skin for 5 years in the region of the gluteal cleft and right thigh anteriorly. Viral screens for HIV I and II, Hepatitis B surface Ag, and Hepatitis C virus antibodies were also negative. Contrast computed tomography (CT) demonstrated tumorous nodular thickening of skin and subcutaneous fat of the gluteal cleft [Figure 1]a and anterior right thigh [Figure 1]b. On laboratory investigations, her hemoglobin was 7.5 g%, total leukocyte count was 8500/mm 3, and platelet count was 240,000/mm 3. Peripheral smear showed no atypical cells. There was no involvement of the bone marrow. FNAC of the skin lesions revealed features compatible with non-Hodgkin's lymphoma. Skin biopsy showed diffuse lymphoid infiltrate involving the full thickness of epidermis and extending to the subcutaneous dermis, more around the perivascular spaces [Figure 2]a. These lymphoid cells were atypical and large with convoluted nuclei. Histopathological diagnosis of mycosis fungoides-tumor stage was made. Immunohistochemistry showed CD3 [Figure 2]b, CD4, and leukocyte common antigen positivity. He was diagnosed in the early stages, stage 1B (T2 N0 M0 B0) according to the modified tumor-node-metastasis-blood classification. The patient was placed on topical glucocorticoids and commenced on eight courses of IV cyclophosphamide 750 mg/m 2, IV epirubicin 25 mg/m 2, and prednisolone tablets 40 mg/m 2 daily for 5 days. Each course was given in 21-day intervals. He completed all courses of chemotherapy and did well, evidenced by disappearance of symptoms except for the dyspigmentation on the skin which is still resolving.
Figure 1: (a) Axial contrast-enhanced computed tomography image showing tumorous nodular thickening of the skin and subcutaneous fat at the region of gluteal cleft (arrow). (b) Axial contrast-enhanced computed tomography image showing tumorous nodular thickening of the skin and subcutaneous fat of anteromedial right proximal thigh (arrow) extending posteriorly

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Figure 2: (a): Histopathology of the skin biopsy showing epidermotropism with a dense band-like dermal infiltrate (H and E, ×200). (b) Immunohistochemistry image of the skin biopsy showing positivity for CD3 (×400)

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Mycosis fungoides is a T-cell lymphoma and an uncommon form of extranodal NHL occurring most commonly in elderly men.[1] Mycosis fungoides is the most common form of cutaneous T-cell lymphoma (CTCL);[2] presents with chronic eczema; can progress to widespread visceral involvement; has a high recurrence rate with survival depending on the presence of nodal and systemic involvement; with low fludeoxyglucose (FDG) uptake. T-cell lymphomas are the most common (65% of cases), and B-cell lymphomas account for the remainder.[3] Histopathology remains the reference standard for the diagnosis of skin malignancies. CTCL is usually polymorphous clinically, whereas cutaneous B-cell lymphoma is monomorphous. Imaging modalities such as CT, magnetic resonance imaging, and 18 F-FDG positron emission tomography/CT are commonly used for staging, preoperative planning, and posttreatment assessment. Imaging findings can narrow down the differential diagnosis and elucidate their metastatic pattern.

Declaration of patient consent

The authors certify that they have obtained all appropriate patient consent forms. In the form the patient(s) has/have given his/her/their consent for his/her/their images and other clinical information to be reported in the journal. The patients understand that their names and initials will not be published and due efforts will be made to conceal their identity, but anonymity cannot be guaranteed.

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Conflicts of interest

There are no conflicts of interest.

  References Top

Arafah M, Zaidi SN, Kfoury HK, Al Rikabi A, Al Ghamdi K. The histological spectrum of early mycosis fungoides: A study of 58 Saudi Arab patients. Oman Med J 2012;27:134-9.  Back to cited text no. 1
Burg G, Dummer R, Haeffner A, Kempf W, Kadin M. From inflammation to neoplasia: Mycosis fungoides evolves from reactive inflammatory conditions (lymphoid infiltrates) transforming into neoplastic plaques and tumors. Arch Dermatol 2001;137:949-52.  Back to cited text no. 2
Inchara YK, Rajalakshmi T. Early mycosis fungoides vs. inflammatory mimics: How reliable is histology? Indian J Dermatol Venereol Leprol 2008;74:462-6.  Back to cited text no. 3
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