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REVIEW ARTICLE
Year : 2016  |  Volume : 2  |  Issue : 1  |  Page : 3-7

An update on newer monoclonal antibodies in lymphoma therapy


1 Department of Internal Medicine, Sir Seewoosagur Ramgoolam Medical College, University of Mauritius, Mauritius
2 Department of Internal Medicine, University of Connecticut, CT, USA
3 Department of Medicine, Baylor College of Medicine, Houston, TX, USA
4 Department of Internal Medicine, Arkansas Cancer Institute, Little Rock, AR, USA

Correspondence Address:
Sandeep Sahay
Department of Internal Medicine, Baylor College of Medicine, 6620 Main St, 11B.12, Houston, TX
USA
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2454-6798.180581

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In 2014, an estimated 9.4% of all new cancers in the US were accounted to hematological cancers. Most of these cancers have a B-cell origin and on the cell surface express antigen CD20-known to restrict B-cells. Considering the intrinsic immune status of the patients receiving chemotherapy, monoclonal antibodies (mAbs) are designed to provide active or passive immunotherapy. Clinical success of rituximab-anti-CD20 mAb in the treatment of lymphoma has led to the development of newer generations of mAb to increase the anti-tumor activity. Hence, recent advances in lymphoma therapy are being built on the conventional prototype of anti-CD20 mAb-rituximab. Our review is an update on the advances in lymphoma therapy using mAb against CD20 including the second generation-ofatumumab, veltuzumab, ocrelizumab, and the third-generation mAbs-ocaratuzumab and obinutuzumab.


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