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Year : 2015  |  Volume : 1  |  Issue : 2  |  Page : 65-72

Molecular oncology update: Breast cancer gene expression profiling

1 Max Cancer Center, Max Hospital, New Delhi, India
2 MolQ Laboratory, Molecular Quest Healthcare Pvt. Ltd., Gurgaon, Haryana, India
3 MolQ Laboratory, Molecular Quest Healthcare Pvt. Ltd., Gurgaon, Haryana, India; Department of Biochemistry and Molecular Biology, University of Maryland, Baltimore, MD; Department of Experimental Therapeutics, University of Texas MD Anderson Cancer Center, Houston, Texas, USA

Correspondence Address:
Amit Verma
Max Cancer Center, Max Hospital, New Delhi
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/2454-6798.173282

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Molecular Oncology has paved its way in the comprehensive cancer care, and its burgeoning role especially in the discovery of novel cellular targets is responsible for emergence of the new Paradigm called "Genomic Paradigm", a shift from the old age "Clinico-Pathological Paradigm". In breast cancer, till recently clinical decisions, prognostications, and predictions were based solely upon histopathologic analysis, or one or a small numbers of genes or their expressions (proteins) in the tumor tissue. With the advent of newer technologies like microarray, which allows us to read the "Molecular Signature" of an individual patient's tumor, the molecular information is exploited for novel targeted treatments and new biomarkers identification. This has led to better classification of cancers for prognostication and treatment selection. In this review we have summarized various Genomic Expression Profiling (GEP) which are available commercially or in different developmental phases.

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